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Reduction of T-kininogen messenger RNA levels by dexamethasone in the adjuvant-treated rat
E F Howard1, Y G Thompson, C A Lapp
1Department of Cell and Molecular Biology, School of Graduate Studies, Medical College of Georgia, Augusta 30912-2100.
Life Sciences
|January 1, 1990
Abstract:
When inflammation is induced in rats following injection of Freund's complete adjuvant, steady state levels of T-I and T-II kininogen mRNAs increase markedly as do plasma levels of T-I and T-II kininogens. When rats are additionally treated with dexamethasone, T-I and T-II steady state mRNA levels and plasma levels of T-kininogens are reduced. The results suggest that dexamethasone may affect the magnitude of T-kininogen gene induction caused by inflammation.