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Postmortem serum tenascin-C (TN-C) concentrations in forensic autopsy cases: A pilot study
Yuki Ohtsu1, Ako Sasao, Kosei Yonemitsu
1Department of Forensic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Legal Medicine (Tokyo, Japan)
|October 10, 2012
Summary
Postmortem serum tenascin-C (TN-C) levels are elevated compared to healthy individuals. High TN-C and C-reactive protein (CRP) indicate head injury, suggesting TN-C aids in identifying fatal trauma causes.
Area of Science:
- Forensic Medicine
- Biochemistry
- Pathology
Background:
- Autopsy findings are crucial for determining cause of death.
- Clinical biochemical markers complement traditional forensic investigations.
- Tenascin-C (TN-C), an extracellular matrix glycoprotein, is implicated in pathological states.
Purpose of the Study:
- To investigate the utility of postmortem serum tenascin-C (TN-C) levels as a biomarker in forensic investigations.
- To analyze the correlation between TN-C, C-reactive protein (CRP), and cause of death in autopsy cases.
Main Methods:
- Retrospective review of 101 autopsy cases from 2006-2009.
- Analysis of postmortem serum concentrations of TN-C and CRP.
- Comparison of TN-C levels between autopsy cases and healthy individuals.
Main Results:
- Postmortem serum TN-C levels were higher than in healthy controls.
- Elevated TN-C and CRP levels were observed in cases of head injury.
- Higher TN-C levels correlated with longer survival periods post-trauma.
Conclusions:
- Postmortem serum TN-C is a potential biomarker for forensic investigations.
- TN-C may assist in identifying specific fatal traumas, especially those with prolonged survival.
- Combined analysis of TN-C and CRP may enhance diagnosis of traumatic injuries.
