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Childhood vesicoureteral reflux studies: registries and repositories sources and nosology

Russell W Chesney1, Andrea B Patters

  • 1Department of Pediatrics, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, 50 N. Dunlap, Memphis, TN 38103, USA.

Journal of Pediatric Urology
|October 10, 2012
PubMed

Insights

Disease registries and biorepositories are crucial for collecting data and samples from children with urinary tract infections (UTIs) and vesicoureteral reflux (VUR). This helps clarify treatment guidelines and understand reflux impacts.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Clinical Informatics

Background:

  • The management of pediatric urinary tract infections (UTIs) and vesicoureteral reflux (VUR) involves ongoing controversies regarding antimicrobial prophylaxis and imaging studies.
  • Assessing the impact of VUR on UTI severity and recurrence rates presents significant challenges.

Purpose of the Study:

  • To highlight the value of disease registries and biorepositories for collecting clinical data and biomaterials from children diagnosed with VUR.
  • To provide an overview of existing registries and repositories that gather information and samples related to VUR in pediatric populations.

Main Methods:

  • Review and description of current disease registries and biorepositories focused on pediatric VUR.
  • Analysis of the heterogeneity in data and sample collection criteria across different registries and repositories.

Main Results:

  • Registries and repositories are essential resources for advancing research in pediatric VUR and UTIs.
  • These resources capture diverse patient populations, including those with primary, syndromic, and secondary reflux.

Conclusions:

  • Establishing and maintaining comprehensive registries and repositories is vital for resolving controversies in pediatric UTI and VUR management.
  • Standardized data and sample collection across these resources will enhance research capabilities and clinical decision-making.

Keywords:
Reflux nephropathyRegistryRepositoryUrinary tract infectionVesicoureteral reflux

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