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Vaccinations

Vaccinations

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Related Experiment Video

Updated: May 17, 2026

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes

Published on: July 12, 2024

Measles vaccination using a microneedle patch.

Chris Edens¹, Marcus L Collins, Jessica Ayers

¹Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, United States.

|October 10, 2012

Summary

This summary is machine-generated.

Measles microneedle patches offer a safer, simpler vaccine delivery method. This study shows microneedle vaccination generates antibody responses comparable to traditional injections, improving vaccine accessibility.

Keywords:

Cotton rat Measles vaccination Microneedle patch Vaccine stability

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Published on: January 30, 2026

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Last Updated: May 17, 2026

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes

Published on: July 12, 2024

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

Area of Science:

Vaccinology
Biomaterials Science
Immunology

Background:

Conventional subcutaneous measles vaccination requires skilled personnel and carries risks of needle-stick injury and disease transmission.
Existing delivery methods face challenges in cost, logistics, and safety, hindering widespread vaccination programs.

Purpose of the Study:

To evaluate the efficacy of a novel microneedle patch system for measles vaccine delivery.
To address limitations of subcutaneous injection, including the need for specialized healthcare professionals and safe needle disposal.

Main Methods:

Stabilizing measles vaccine virus on microneedles using trehalose for enhanced shelf-life at room temperature.
Applying microneedle patches coated with the Edmonston-Zagreb measles vaccine strain to immunize cotton rats.
Comparing antibody responses generated by microneedle vaccination with those from conventional subcutaneous injection.

Main Results:

Measles vaccine virus remained viable on microneedle patches for over 30 days at room temperature with minimal titer loss.
Microneedle vaccination in cotton rats, at both standard and reduced doses, elicited neutralizing antibody levels equivalent to subcutaneous injection.
The microneedle patch system demonstrated efficient in vivo reconstitution of the vaccine.

Conclusions:

Measles vaccine can be effectively stabilized on microneedle patches for improved delivery.
Microneedle patch vaccination elicits a robust neutralizing antibody response comparable to subcutaneous injection.
This technology holds potential for simplified, safer, and more accessible measles immunization strategies.