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Updated: May 17, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Autoimmune thyroiditis presenting as interstitial granulomatous dermatitis.

Joana Antunes¹, David Pacheco, Ana Rita Travassos

¹Dermatology Service, Santa Maria Hospital, Hospital Center North Lisbon, Portugal. joanaferroantunes@gmail.com

Anais Brasileiros De Dermatologia

|October 10, 2012

Summary

Interstitial granulomatous dermatitis, a rare skin condition, was observed in a patient with autoimmune thyroiditis. While topical corticosteroids offered temporary relief, the association highlights a rare link between skin inflammation and thyroid autoimmunity.

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Area of Science:

Dermatology
Endocrinology
Immunology

Background:

Interstitial granulomatous dermatitis (IGD) is a rare inflammatory skin reaction with diverse clinical presentations.
IGD is typically associated with drugs, lymphoproliferative disorders, and autoimmune diseases like rheumatoid arthritis and lupus erythematosus.

Observation:

A 54-year-old female presented with a 3-month history of widespread, painful, erythematous plaques.
Skin biopsy confirmed interstitial granulomatous dermatitis.
Investigations revealed hypothyroidism with positive anti-thyroid antibodies.

Findings:

The patient's dermatosis showed only transient improvement despite normalized thyroid function and potent topical corticosteroid treatment.
The association between interstitial granulomatous dermatitis and autoimmune thyroiditis is notably rare.

Implications:

This case underscores the importance of considering autoimmune conditions, including rare thyroid associations, in the differential diagnosis of IGD.
Further research is needed to establish optimal therapeutic strategies for IGD, particularly in the context of autoimmune comorbidities.
The condition's characteristic pattern of flares and remissions necessitates long-term management considerations.