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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
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Updated: May 17, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Overview of hepatotoxicity.

¹University of Louisiana-Monroe, Monroe, Louisiana, USA.

Current Protocols in Toxicology

|October 10, 2012

Summary

This summary is machine-generated.

This overview explores liver biology and chemical histopathology, examining hepatotoxicity risks from EPA chemicals. It assesses the scope of chemically-induced liver damage and available analytical methods.

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Area of Science:

Hepatotoxicity and chemical pathology
Liver biology and physiology

Background:

Understanding liver function is crucial for studying chemical impacts.
Hepatotoxicity is a significant concern with various chemical exposures.

Purpose of the Study:

To review key aspects of liver biology and physiology relevant to toxicological studies.
To examine the prevalence and risk of hepatotoxicity from chemicals in the EPA IRIS database.
To provide an objective assessment of chemically-induced hepatotoxicity.

Main Methods:

Literature review of liver biology and physiology.
Analysis of chemical data from the EPA IRIS database.
Examination of experimental tools for chemical histopathology.

Main Results:

Identified salient features of liver biology and physiology.
Assessed prevalence and risk of hepatotoxicity for a subset of EPA chemicals.
Provided context for liver responses to toxicants and analytical methods.

Conclusions:

Chemically-induced hepatotoxicity presents a significant challenge.
A comprehensive understanding of liver responses and analytical methods is essential for risk assessment.