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Updated: May 17, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Overview of hepatotoxicity
1University of Louisiana-Monroe, Monroe, Louisiana, USA.
Abstract:
This overview presents some of the salient features of liver biology and physiology that form the basis for a variety of experimental tools that are used for the study of chemical histopathology. Prevalence and risk of heptatoxicity are examined among a subset of chemicals from the EPA IRIS database. The goal is to provide an objective assessment of the magnitude of the problem of chemically-induced hepatotoxicity and contextual background against which the diversity of responses of the liver to toxicants and the analytical methods available for their study can be appreciated.
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