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Updated: May 17, 2026
11:06
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Overview of hepatotoxicity.
1University of Louisiana-Monroe, Monroe, Louisiana, USA.
Current Protocols in Toxicology
|October 10, 2012
Summary
This overview explores liver biology and chemical histopathology, examining hepatotoxicity risks from EPA chemicals. It assesses the scope of chemically-induced liver damage and available analytical methods.
Area of Science:
- Hepatotoxicity and chemical pathology
- Liver biology and physiology
Background:
- Understanding liver function is crucial for studying chemical impacts.
- Hepatotoxicity is a significant concern with various chemical exposures.
Purpose of the Study:
- To review key aspects of liver biology and physiology relevant to toxicological studies.
- To examine the prevalence and risk of hepatotoxicity from chemicals in the EPA IRIS database.
- To provide an objective assessment of chemically-induced hepatotoxicity.
Main Methods:
- Literature review of liver biology and physiology.
- Analysis of chemical data from the EPA IRIS database.
- Examination of experimental tools for chemical histopathology.
Main Results:
- Identified salient features of liver biology and physiology.
- Assessed prevalence and risk of hepatotoxicity for a subset of EPA chemicals.
- Provided context for liver responses to toxicants and analytical methods.
Conclusions:
- Chemically-induced hepatotoxicity presents a significant challenge.
- A comprehensive understanding of liver responses and analytical methods is essential for risk assessment.
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