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Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

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Related Experiment Video

Updated: May 17, 2026

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

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Diffusion tensor imaging and tractography in Brown-Sequard syndrome.

A Vedantam1, M B Jirjis, B D Schmit

  • 1Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Spinal Cord
|October 10, 2012
PubMed
Summary
This summary is machine-generated.

Diffusion tensor imaging (DTI) and tractography effectively visualized cervical cord damage in two patients with Brown-Sequard syndrome. These advanced MRI techniques revealed injury patterns correlating with neurological deficits, aiding in diagnosis and treatment planning for spinal cord injury.

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Area of Science:

  • Neuroimaging
  • Spinal Cord Injury Research
  • Advanced MRI Techniques

Background:

  • Brown-Sequard syndrome, characterized by hemisection of the spinal cord, often results from penetrating trauma.
  • Accurate assessment of the extent and location of cervical cord injury is crucial for patient management.
  • Conventional MRI may not fully delineate the complex fiber tract damage in acute spinal cord injuries.

Observation:

  • This case report details the application of diffusion tensor imaging (DTI) and tractography in two patients with Brown-Sequard syndrome following stab wounds to the neck.
  • Cervical cord imaging was performed within one week of injury.
  • DTI metrics and tractography were used to visualize the injured spinal cord segments and associated white matter tracts.

Findings:

  • Diffusion tensor imaging revealed significantly reduced fractional anisotropy (FA) in the injured hemicord, indicating unilateral cord damage.
  • Tractography successfully visualized the disrupted fiber tracts at the injury site.
  • Both DTI metrics and tractography demonstrated an asymmetry that correlated with the patients' specific neurological deficits.

Implications:

  • Diffusion tensor imaging and tractography are valuable tools for delineating the precise regions of cord injury in traumatic Brown-Sequard syndrome.
  • These advanced imaging modalities provide clinically relevant information that complements standard MRI in acute spinal cord injury (SCI).
  • The findings support the utility of DTI and tractography in improving the diagnostic accuracy and understanding of SCI pathophysiology.