Related Experiment Video
Updated: May 17, 2026
06:26
Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry
Published on: December 9, 2025
Face and neck swelling in a 16-year-old boy.
Erin Peebles1, Chitra Pushpanathan, Syed Pirzada
1Department of Pediatrics, Memorial University, St. John's, Canada. epeebles@mun.ca
BMJ Case Reports
|October 10, 2012
Summary
Scleredema adultorum, a rare skin condition, can be triggered by infections like streptococcal. This case highlights a potential link with Epstein-Barr virus (EBV) in a teen with neck swelling.
Area of Science:
- Dermatology
- Infectious Diseases
Background:
- Scleredema adultorum is a rare connective tissue disorder characterized by mucin deposition and skin induration.
- Its etiology is often unclear but frequently associated with preceding infections.
Observation:
- A previously healthy 16-year-old male presented with progressive neck swelling and skin hardening over three weeks.
- The patient exhibited concurrent active streptococcal and Epstein-Barr virus (EBV) infections.
Findings:
- Skin biopsy confirmed scleredema adultorum.
- Treatment of the streptococcal infection and conservative management led to significant symptom improvement within three months.
- This case is the first reported instance of scleredema associated with EBV infection.
Implications:
- Scleredema adultorum should be considered in the differential diagnosis of neck and facial swelling with skin induration.
- The findings suggest a potential association between EBV infection and scleredema, expanding the known infectious triggers.
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