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Updated: May 17, 2026
Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants
Published on: May 4, 2018
Draft genome sequence of the Pseudomonas aeruginosa bloodstream isolate PABL056
Egon A Ozer1, Jonathan P Allen, Alan R Hauser
1Department of Medicine, Division of Infectious Diseases, Northwestern University, Chicago, Illinois, USA. e-ozer@md.northwestern.edu
Abstract:
Pseudomonas aeruginosa is an important cause of disease in hospitalized and immunocompromised patients. The genome of P. aeruginosa is among the largest of bacteria pathogenic to humans. We present the draft genome sequence of P. aeruginosa strain PABL056, a human bloodstream isolate with the largest genome yet reported in P. aeruginosa.
Insights
We sequenced the genome of Pseudomonas aeruginosa strain PABL056, a human bloodstream isolate. This bacterium has the largest genome reported for Pseudomonas aeruginosa, a significant pathogen in healthcare settings.
Area of Science:
- Microbiology
- Genomics
- Bacterial Pathogenesis
Background:
- Pseudomonas aeruginosa is a significant opportunistic pathogen.
- It causes severe infections in hospitalized and immunocompromised individuals.
- The bacterium possesses one of the largest known bacterial genomes.
Purpose of the Study:
- To present the draft genome sequence of P. aeruginosa strain PABL056.
- To characterize a P. aeruginosa isolate with an exceptionally large genome.
Main Methods:
- Whole-genome sequencing of P. aeruginosa strain PABL056.
- Bioinformatic analysis of the resulting genome data.
Main Results:
- The draft genome sequence of P. aeruginosa strain PABL056 was successfully generated.
- Strain PABL056 exhibits the largest genome size reported to date for P. aeruginosa.
- The isolate was obtained from a human bloodstream infection.
Conclusions:
- The genome sequence of P. aeruginosa strain PABL056 provides valuable insights into the genetic basis of this pathogen.
- Understanding large bacterial genomes can aid in developing targeted therapeutic strategies against P. aeruginosa infections.
