Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix01:42

The Extracellular Matrix

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rethinking CAR-T manufacturing paradigms: terminology, operational considerations, and economic trade-offs.

Cytotherapy·2026
Same author

Cardiorenal Hemodynamic Coupling: Mechanical Circulatory Support Augments Renal Blood Flow via Renal Vasodilation.

JACC. Basic to translational science·2026
Same author

Flow-mediated endothelial remodeling and inflammation drive developmental vascular susceptibility in ldlr loss of function.

Nature communications·2026
Same author

Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging.

Ageing research reviews·2026
Same author

Toward Smart and Adaptive Endovascular Devices: The Role of Digital Twins in Precision Vascular Medicine.

Interventional cardiology clinics·2026
Same author

Endovascular Drug Delivery from Stents and Balloons in Peripheral Arteries: What Every Interventionalist Must Know.

Interventional cardiology clinics·2026
Same journal

Metal-Organic Framework Multizyme Colloids with Joint Antioxidant and Protease Function.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Morphology Engineering of Co<sub>3</sub>O<sub>4</sub> via Cetyltrimethylammonium Bromide-Mediated ZIF-67 Synthesis for Efficient Photo-Assisted Electrooxidation of Methanol.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Speciation of Silanol Groups on Commercial Precipitated Silicas via IR Spectroscopy.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Regenerable PVA Hydrogel-Functionalized Optical Fiber Sensor for Ultra-Trace Detection of Berberine Hydrochloride.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Hydrogen Plasma-Driven Surface Defect Engineering of ZnO Nanorods: Correlating Electronic Structure and Photoelectrochemical Performance.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Cooperative Self-Assembly of Nanoparticle-Encapsulating Hybrid Protein Cages.

Langmuir : the ACS journal of surfaces and colloids·2026
See all related articles

Related Experiment Video

Updated: May 17, 2026

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
08:02

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Published on: July 3, 2018

Natural tissue microenvironmental conditions modulate adhesive material performance.

Nuria Oliva1, Sagi Shitreet, Eytan Abraham

  • 1Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|October 11, 2012
PubMed
Summary
This summary is machine-generated.

Researchers developed adaptable tissue adhesives by matching material and biological properties. These novel biomaterials demonstrate tunable adhesion for specific intestinal regions, optimizing performance through tailored chemical interactions.

More Related Videos

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
07:50

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Published on: June 2, 2020

Environmentally-controlled Microtensile Testing of Mechanically-adaptive Polymer Nanocomposites for ex vivo Characterization
11:38

Environmentally-controlled Microtensile Testing of Mechanically-adaptive Polymer Nanocomposites for ex vivo Characterization

Published on: August 20, 2013

Related Experiment Videos

Last Updated: May 17, 2026

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
08:02

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Published on: July 3, 2018

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
07:50

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Published on: June 2, 2020

Environmentally-controlled Microtensile Testing of Mechanically-adaptive Polymer Nanocomposites for ex vivo Characterization
11:38

Environmentally-controlled Microtensile Testing of Mechanically-adaptive Polymer Nanocomposites for ex vivo Characterization

Published on: August 20, 2013

Area of Science:

  • Biomaterials Science
  • Chemical Engineering
  • Tissue Engineering

Background:

  • Developing effective tissue adhesives requires understanding and matching material properties with specific biological microenvironments.
  • Existing adhesives often lack specificity, leading to suboptimal performance on diverse tissue types.

Purpose of the Study:

  • To design and optimize tissue-responsive adhesive materials by aligning material characteristics with specific tissue properties.
  • To investigate the influence of varying tissue amine density across different small intestine regions (duodenum, jejunum, ileum) on adhesive material interactions.
  • To demonstrate the ability to tune adhesive strength for specific intestinal segments by modifying adhesive formulation.

Main Methods:

  • A two-component adhesive system based on dextran aldehyde and dendrimer amine was synthesized.
  • Aldehyde-amine cross-linking was utilized for cohesive gel formation, while dextran aldehyde's selective reaction with tissue amines formed the adhesive interface.
  • Variations in aldehyde content within the adhesive were correlated with tissue amine density in different intestinal regions to assess adhesion.
  • Interfacial morphology, adhesion strength, and mechanical properties were analyzed based on tissue-specific interactions.

Main Results:

  • The same adhesive formulation exhibited differential reactivity with the duodenum, jejunum, and ileum due to variations in serosal amine density.
  • Tissue amine density directly impacted the tissue-material interfacial morphology, adhesion strength, and mechanical properties of the adhesive.
  • Adhesion strength could be precisely controlled for each intestinal region by adjusting the aldehyde/amine ratio in the two-component adhesive system.

Conclusions:

  • Material design must consider specific microenvironmental conditions, such as tissue amine density, for optimal performance.
  • A tissue-specific approach to biomaterial design, exemplified by these tunable adhesives, is crucial for broad applications.
  • This study provides a framework for developing responsive biomaterials that adapt to the unique chemical landscape of target tissues.