Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vosamidines A-C, Polycyclic 2-Aminoimidazole Alkaloids from a Marine Calcareous Sponge <i>Vosmaeropsis wilsoni</i>.

Organic letters·2026
Same author

Community-led standards for global wastewater-based infectious disease surveillance.

PLOS global public health·2026
Same author

Nanodomain Formation and Temperature-Dependent Diffusion in Deep Eutectic Solvents Revealed by Single-Molecule Tracking.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Temperature-dependent changes in gas chromatographic separation metrics for trihexyl(tetradecyl)phosphonium-based ionic liquid stationary phases and comparison to conventional polysiloxane stationary phases.

Journal of chromatography. A·2026
Same author

Inequities and global declines in SARS-CoV-2 genomic data availability hinder response to emerging variants.

Npj viruses·2026
Same author

Use cases for pan-sarbecovirus vaccines: a workshop report.

Vaccine·2026

Related Experiment Video

Updated: May 17, 2026

Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems
07:44

Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems

Published on: April 28, 2016

Plasmon waveguide resonance Raman spectroscopy.

Kristopher J McKee1, Matthew W Meyer, Emily A Smith

  • 1Ames Laboratory, U.S. Department of Energy, Ames, Iowa 50011-3111, United States.

Analytical Chemistry
|October 11, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces a plasmon waveguide resonance (PWR) interface for enhanced surface-sensitive Raman spectroscopy. The novel interface significantly boosts signal detection for analytes like pyridine and polystyrene films.

More Related Videos

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
06:19

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations

Published on: June 23, 2022

A Multimodal Wide-Field Fourier-Transform Raman Microscope
06:48

A Multimodal Wide-Field Fourier-Transform Raman Microscope

Published on: December 30, 2025

Related Experiment Videos

Last Updated: May 17, 2026

Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems
07:44

Resonance Raman Spectroscopy of Extreme Nanowires and Other 1D Systems

Published on: April 28, 2016

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations
06:19

Optical Trapping of Plasmonic Nanoparticles for In Situ Surface-Enhanced Raman Spectroscopy Characterizations

Published on: June 23, 2022

A Multimodal Wide-Field Fourier-Transform Raman Microscope
06:48

A Multimodal Wide-Field Fourier-Transform Raman Microscope

Published on: December 30, 2025

Area of Science:

  • Surface science
  • Spectroscopy
  • Nanotechnology

Background:

  • Traditional Raman spectroscopy often lacks sufficient surface sensitivity for detecting thin films or monolayers.
  • Plasmonic interfaces can enhance electromagnetic fields, boosting Raman signals, but require specific polarization.
  • Total internal reflection (TIR) configurations are used to probe interfaces, but signal enhancement can be limited.

Purpose of the Study:

  • To develop and characterize a plasmon waveguide resonance (PWR) interface for enhanced surface-sensitive Raman spectroscopy.
  • To investigate the signal enhancement and polarization control capabilities of the PWR interface compared to conventional methods.
  • To demonstrate the application of the PWR interface for detecting thin films and monolayers with improved sensitivity.

Main Methods:

  • Raman spectra were collected from aqueous pyridine, polystyrene films, and silane monolayers at a plasmon waveguide interface under total internal reflection (TIR).
  • The PWR interface comprised a sapphire prism, gold film, and silicon dioxide layer.
  • Measurements were taken at varying incident angles using a 785-nm excitation wavelength and compared to bare sapphire or gold interfaces.

Main Results:

  • The PWR interface demonstrated significantly increased surface sensitivity and signal enhancement compared to a bare sapphire prism.
  • Unlike bare gold films, the PWR interface allowed excitation with both s- and p-polarized light, enabling polarization control.
  • A high signal-to-noise ratio (5.6) was achieved for a monolayer at the PWR interface, while no signal was detected at the sapphire interface.

Conclusions:

  • The developed plasmon waveguide resonance interface offers enhanced surface sensitivity and signal amplification for Raman spectroscopy.
  • This technique adds chemical specificity to PWR spectroscopy, provides a signal enhancement mechanism for TIR Raman spectroscopy, and allows polarization control for SPR Raman spectroscopy.
  • The PWR interface represents a significant advancement for sensitive interfacial analysis using Raman spectroscopy.