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Updated: May 17, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Tocolytic therapy for preterm delivery: systematic review and network meta-analysis.

David M Haas¹, Deborah M Caldwell, Page Kirkpatrick

¹Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA. dahaas@iupui.edu

BMJ (Clinical Research Ed.)

|October 11, 2012

Summary

Prostaglandin inhibitors and calcium channel blockers are the most effective tocolytic agents for delaying delivery. These drugs also show promise in improving neonatal and maternal outcomes, offering a better safety profile compared to other tocolytics.

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Transcutaneous Microcirculatory Imaging in Preterm Neonates

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Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

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Area of Science:

Obstetrics and Gynecology
Pharmacology
Neonatal Medicine

Background:

Preterm delivery poses significant risks to neonatal and maternal health.
Tocolytic agents are used to inhibit uterine contractions and delay childbirth.
The comparative effectiveness of different tocolytic classes remains an area of active research.

Purpose of the Study:

To identify the most effective tocolytic agent for delaying delivery in women at risk of preterm birth.
To compare the efficacy and safety profiles of various tocolytic drug classes.

Main Methods:

A systematic review and network meta-analysis of randomized controlled trials (RCTs) were conducted.
Data from 95 RCTs involving tocolytic therapy were analyzed.
Outcomes assessed included delay in delivery, neonatal respiratory distress syndrome, neonatal mortality, and maternal side effects.

Main Results:

Prostaglandin inhibitors demonstrated the highest probability of delaying delivery by 48 hours compared to placebo.
Magnesium sulfate, calcium channel blockers, beta mimetics, and atosiban also showed significant delay in delivery compared to placebo.
Beta mimetics, magnesium sulfate, and calcium channel blockers were associated with significantly higher rates of maternal side effects requiring medication changes.

Conclusions:

Prostaglandin inhibitors and calcium channel blockers appear to be the most effective tocolytic agents for delaying delivery.
These drug classes also show potential for improving neonatal and maternal outcomes with a favorable safety profile.