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Updated: May 17, 2026

Analysis of Transgenerational Epigenetic Inheritance in C. elegans Using a Fluorescent Reporter and Chromatin Immunoprecipitation (ChIP)
Published on: May 5, 2023
Epigenetic memory and parliamentary privilege combine to evoke discussions on inheritance
Amanda G Fisher1, Neil Brockdorff
1Lymphocyte Development Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, Du Cane Road, London W12 ONN, UK. amanda.fisher@csc.mrc.ac.uk
Abstract:
Understanding the basis of epigenetic memory is a fast-moving challenge in modern biology. At a recent Company of Biologists Workshop held at Steyning's historic Wiston House, thirty researchers led by John Gurdon interrogated three central questions: how are cell type-specific programs generated, what mechanisms duplicate this programmatic information as cells divide, and how does epigenetics contribute to trans-generational inheritance? We report some of the emerging themes arising from this debate.
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