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Related Concept Videos

Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

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Related Experiment Video

Updated: May 17, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Nucleic acid-based nanoengineering: novel structures for biomedical applications.

Hanying Li1, Thomas H Labean, Kam W Leong

  • 1Department of Biomedical Engineering , Duke University , 136 Hudson Hall, PO Box 90281, Durham, NC 27708 , USA.

Interface Focus
|October 11, 2012
PubMed
Summary
This summary is machine-generated.

Nucleic acid nanoengineering uses DNA/RNA base-pairing to build precise nanostructures. These functional nucleic acid nanodevices show promise for nanomedicine and advanced molecular applications.

Keywords:
DNAdrug deliverynanomedicineorigamiself-assemblytemplated display

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Last Updated: May 17, 2026

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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Biology

Background:

  • Nanoengineering leverages nanoscale material interactions for functional structures.
  • Nucleic acids, through Watson-Crick base-pairing, offer precise molecular recognition and assembly capabilities.
  • DNA/RNA's versatility enables the creation of complex 2D and 3D nanostructures.

Purpose of the Study:

  • To review strategies for controlling nucleic acid assembly.
  • To highlight recent advancements in functional nucleic acid nanodevices.
  • To explore applications in nanomedicine.

Main Methods:

  • Creative assembly of nucleic acids into defined nanostructures.
  • Precise spatial functionalization of nanostructures with molecules, proteins, and nanoparticles.
  • Engineering nanostructures for stimulus-responsive encapsulation and release of bioactive agents.

Main Results:

  • Development of 2D and 3D nucleic acid nanostructures with controlled size, shape, and functionality.
  • Applications in single-molecule chemical reaction observation, enzymatic cascade activation, and photonic detection.
  • Demonstration of stimulus-responsive drug delivery systems using nucleic acid nanostructures.

Conclusions:

  • Nucleic acid nanoengineering offers a powerful platform for creating sophisticated functional nanodevices.
  • These nanodevices have significant potential in nanomedicine, diagnostics, and fundamental research.
  • The field is rapidly advancing, with future applications limited only by imagination.