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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Weight status in persons with multiple sclerosis: implications for mobility outcomes.

Lara A Pilutti1, Deirdre Dlugonski, John H Pula

  • 1Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 233 Freer Hall, Urbana, IL 61801, USA.

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|October 11, 2012
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Summary

Excess body weight in multiple sclerosis (MS) did not significantly impact mobility outcomes like walking speed or daily activity levels in this study. Further research is needed to identify other factors affecting ambulatory performance in MS patients.

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Area of Science:

  • Neurology
  • Exercise Science
  • Public Health

Background:

  • Excess body weight is a growing concern with potential health implications for individuals with multiple sclerosis (MS).
  • Understanding the relationship between weight status and mobility is crucial for managing MS and maintaining functional independence.

Purpose of the Study:

  • To investigate the impact of body mass index (BMI) on a comprehensive range of mobility outcomes in ambulatory individuals with MS.
  • To determine if overweight and obesity significantly affect gait parameters, walking performance, and daily physical activity in this population.

Main Methods:

  • The study included 168 ambulatory persons with MS, assessing their weight status via BMI.
  • Mobility was evaluated using multiple measures: timed 25-foot walk (T25FW), 6-minute walk (6MW), oxygen cost of walking (C(w)), gait spatiotemporal parameters, self-reported walking impairment (MSWS-12), and accelerometry for free-living activity.
  • Participants were categorized into normal weight, overweight, and obese groups based on BMI.

Main Results:

  • Nearly 70% of the 168 participants were classified as overweight or obese (BMI ≥ 25 kg/m²).
  • No significant differences were found among BMI groups for T25FW, 6MW, C(w), spatiotemporal gait parameters, MSWS-12 scores, or daily step and movement counts.
  • Despite a high prevalence of overweight and obesity, weight status did not consistently or significantly influence the measured mobility outcomes.

Conclusions:

  • The findings suggest that weight status, as defined by BMI, may not be a primary determinant of mobility in ambulatory individuals with MS.
  • The lack of a significant effect highlights the need to explore other contributing factors that influence ambulatory performance in this population.
  • Future research should focus on identifying these alternative factors to develop more targeted interventions for improving mobility in persons with MS.