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Published on: September 9, 2015
Stability of vancomycin in SyrSpend SF
Paul A Whaley1, Mark A Voudrie
1Dynalabs, LLC, St. Louis, MO, USA.
International Journal of Pharmaceutical Compounding
|October 12, 2012
Summary
Vancomycin oral suspensions compounded with SyrSpend SF are stable for at least 90 days when refrigerated. This provides a viable alternative for patients unable to take capsules for Clostridium difficile infections.
Area of Science:
- Pharmaceutical Sciences
- Drug Stability
- Compounding Pharmacy
Background:
- Oral vancomycin is crucial for treating Clostridium difficile infections.
- Existing formulations (capsules) are unsuitable for all patients.
- Compounding pharmacies require alcohol- and sorbitol-free suspending agents.
Purpose of the Study:
- To evaluate the stability of vancomycin in SyrSpend SF, an alcohol- and sorbitol-free suspending agent.
- To determine the beyond-use date for a compounded vancomycin suspension.
Main Methods:
- A 50-mg/mL vancomycin suspension was prepared using SyrSpend SF.
- Samples were stored at 2-8°C in low-actinic plastic bottles for 90 days.
- Stability was assessed using a validated stability-indicating high-performance liquid chromatography method.
Main Results:
- Vancomycin concentration remained within 90%-110% of the initial value throughout the 90-day study.
- The suspension demonstrated stability under refrigerated conditions, protected from light.
Conclusions:
- Vancomycin compounded in SyrSpend SF is stable for at least 90 days when refrigerated.
- This formulation offers a stable, alternative dosage form for patients requiring oral vancomycin.
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