Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Degradation study of thiamine hydrochloride and analysis of expired ampoules using a novel, validated HPLC-UV method.

Journal of pharmaceutical and biomedical analysis·2026
Same author

Dynamic Pharmacophores Unveil Binding Mode Ensembles for Classical Partial Agonists at the M2 Receptor.

Journal of chemical information and modeling·2026
Same author

Stability of expired tropane alkaloid ampoules using HPLC-UV/CAD.

Journal of pharmaceutical and biomedical analysis·2025
Same author

[Summary of the update to the S3 guideline: Epidemiology, diagnosis and treatment of adult patients with nosocomial pneumonia].

Pneumologie (Stuttgart, Germany)·2025
Same author

Mechanochemical Degradation of Active Pharmaceutical Ingredients (APIs): A Simple Tool for the Prediction of Drug Stability.

Chimia·2025
Same author

Comparison of Quantification Using UV-Vis, NMR, and HPLC Methods of Retinol-Like Bakuchiol Present in Cosmetic Products.

International journal of molecular sciences·2025

Related Experiment Video

Updated: May 17, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

[MRSA--development, distribution and prevention].

Ulrike Holzgrabe1, Marianne Abele-Horn

  • 1Institut für Pharmazie und Lebensmittelchemie, Am Hubland, 97074 Würzburg. u.holzgrabe@pharmazie.uni-wuerzburg.de

Medizinische Monatsschrift Fur Pharmazeuten
|October 12, 2012
PubMed
Summary
This summary is machine-generated.

Multiresistant Staphylococcus aureus (MRSA) infections pose a significant healthcare challenge due to limited effective antibiotics. This article discusses MRSA development, spread, and prevention strategies for healthcare settings.

Related Experiment Videos

Last Updated: May 17, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Context:

  • Multiresistant Staphylococcus aureus (MRSA) is a growing global health concern.
  • Increasing prevalence of MRSA in both hospital-acquired and community-acquired infections.
  • Shortage of potent antibiotics exacerbates the MRSA problem.

Purpose:

  • To provide a comprehensive overview of MRSA.
  • To detail the pathogenesis and epidemiology of MRSA.
  • To offer practical guidance on MRSA infection avoidance and patient management.

Summary:

  • The article reviews the development, pathogenesis, and epidemiology of MRSA.
  • It highlights the challenges posed by antibiotic resistance in Staphylococcus aureus.
  • Practical advice is provided for preventing MRSA transmission and managing infected patients.

Impact:

  • Aims to improve infection control measures against MRSA.
  • Contributes to better understanding and management of antibiotic-resistant bacteria.
  • Supports healthcare professionals in combating MRSA outbreaks.