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[Effect of deep-sea fish oil on improving memory in mice]
Qiang Zeng1, Jingshu Zhang, Zhonghui Liu
1Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China. zengqiang@cdctj.gov.cn
Objective:
To investigate the effects of deep-sea fish oil on improving memory in mice.
Methods:
One hundred and twenty male Kunming mice were allocated randomly into four groups: the control group and low-, medium-and high-dose group, and each group was administrated daily with deep-sea fish oil of 0, 0.15, 0.30 and 0.60 g/kg BW respectively per day for 30 days. The effects of deep-sea fish oil on memory were investigated by step-down test, step-through test and water maze tests.
Results:
In the medium-dose group, the latency phase was prolonged in the step-down test, and the time reached to the final point in the water maze test was shorter (P < 0.05). The indicators of passive avoidance test were not different statistically between fish oil groups and control group (P > 0.05).
Conclusion:
Deep-sea fish oil may play an important role in memory improvement in mice.
