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[Primary study of joint estrogenic activity of Cd2+, Pb2+, parathion and dimethoate]
Shujing Zhang1, Yanbo Yu, Peng Zang
1State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, 10094 Beijing China.
Objective:
To study joint estrogenic activity of Cd2+, Pb2+, parathion and dimethoate in immature female mice.
Methods:
192 17 day-age immature female mice of ablactation were divided randomly by body weight (25g +/- 2g) into 16 groups by intraperitoneal injection at the dose of 0, 1/20LD50, 1/50LD50, 1/100LD50 Cd2+, 1/ 20LD50, 1/50LD50, 1/100LD50 Pb2+, 1/20LD50, 1/50LD50, 1/100LD50 Parathion, 1/ 20LD50, 1/50LD50, 1/100LD52 Dimethoate and 1/20LD50, 1/50LD50, 1/100LD50 Cd2+ + Pb2+ + Parathion + Dimethoat per day for 3 consecutive days. Uteruses wet weight, endometrial cells and ER were measured.
Results:
Compared with the control group, 1/ 50LD50 Cd2+, 1/50LD50 Pb2+ and 1/100LD50 Cd2+ + Pb2+ + Parathion + Dimethoate significantly changed uteruses wet weight, 1/20LD50, 1/50LD50, 1/100LD50 Cd2+, 1/ 20LD50 Pb2+, and 1/20LD50, 1/50LD50 Cd2+ + Pb2+ + Parathion + Dimethoate significantly increased endometrial cells, all treated groups' ER were significantly increased except for 1/20LD50 and 1/50LD50 Cd2+ and 1/20LD50 Parathion.
Conclusion:
There are significant difference between singal factor and joint activity, IN joint activity, Addition effect, synergism and antagonism occurred in different treated groups and different index.
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