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Related Concept Videos

Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 17, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
06:40

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

[Cancer and infertility].

Kirsten Tryde Schmidt1, Anders Nyboe Andersen, Anne Loft

  • 1Fertilitetsklinikken, Rigshospitalet, Blegdamsvej 9, Copenhagen. kirsten.tryde.schmidt@rh.regionh.dk

Ugeskrift for Laeger
|October 12, 2012
PubMed
Summary
This summary is machine-generated.

Cancer treatments like chemotherapy and radiation can cause infertility. Fertility preservation methods, such as sperm, egg, embryo, or ovarian tissue cryopreservation, should be discussed with patients undergoing cancer therapy.

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Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery
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Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery

Published on: May 16, 2018

Related Experiment Videos

Last Updated: May 17, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
06:40

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery
07:40

Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery

Published on: May 16, 2018

Area of Science:

  • Oncology
  • Reproductive Medicine
  • Medical Science

Context:

  • Cancer patients face potential gonadal dysfunction as a side effect of treatments like chemotherapy and radiation.
  • Specific therapies, including alkylating agents and abdominal/testicular radiation, significantly elevate the risk of gonadal failure.
  • Fertility loss impacts both male and female cancer survivors, necessitating proactive reproductive health strategies.

Purpose:

  • To inform about the risk of gonadal dysfunction in cancer patients due to treatment.
  • To highlight the availability and importance of fertility preservation options.
  • To provide an overview of established methods for preserving reproductive potential in men and women.

Summary:

  • Cancer treatments, particularly chemotherapy and radiation, can lead to irreversible gonadal failure.
  • Fertility preservation techniques are crucial for patients undergoing such treatments.
  • Available methods include semen cryopreservation for men, and oocyte, embryo, or ovarian tissue cryopreservation for women.

Impact:

  • Ensures that cancer patients are aware of and can access fertility preservation options before treatment.
  • Empowers patients to make informed decisions regarding their reproductive future.
  • Contributes to improved quality of life for cancer survivors by addressing long-term reproductive health concerns.