Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating Safety Concerns for Pediatric Mental and Behavioral Health Patients and Providers in the Emergency Department: A Systems Perspective.

Journal of patient safety·2025
Same author

Using patient journey mapping and provider workflows to understand process barriers to pediatric mental and behavioral health care in emergency departments.

Applied ergonomics·2025
Same author

Technological barriers to providing pediatric mental and behavioral healthcare in emergency departments.

Applied ergonomics·2024
Same author

Adherence, health care utilization, and costs between long-acting injectable and oral antipsychotic medications in South Carolina Medicaid beneficiaries with schizophrenia.

Journal of managed care & specialty pharmacy·2024
Same author

Harbingers of Hope: Scientists and the Pursuit of World Peace.

Clinical psychology in Europe·2024
Same author

Artificial intelligence is set to transform mental health services.

CNS spectrums·2023
Same journal

The role of the commission on higher education in strengthening student mental health support in Philippine higher education institutions: A policy-to-practice perspective.

Asian journal of psychiatry·2026
Same journal

Large language models in psychiatry: When personalization risks inconsistency in safety communication.

Asian journal of psychiatry·2026
Same journal

Rapid clinical improvement after intravenous ketamine in an adolescent with treatment-resistant depression, severe obesity, and pseudo-Cushing syndrome: A case report.

Asian journal of psychiatry·2026
Same journal

Peripheral GABA-A receptor phosphorylation as a correlate of PMDD severity relative to ovarian hormone markers.

Asian journal of psychiatry·2026
Same journal

Different profiles of multi-dimensional symptoms and psychological characteristics and their related suicide behavior among college students with psychotic-like experiences.

Asian journal of psychiatry·2026
Same journal

Cultural-digital integrative model for mental health in the Middle East (CDMH Model): A theoretically grounded and operational framework.

Asian journal of psychiatry·2026
See all related articles

Related Experiment Video

Updated: May 17, 2026

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:54

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

Treating depression and achieving remission.

Meera Narasimhan1, Melissa H Kannaday

  • 1Department of Psychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, SC, United States.

Asian Journal of Psychiatry
|October 12, 2012
PubMed
Summary
This summary is machine-generated.

Achieving remission from depression remains challenging despite advances. Strategies like destigmatization, patient education, and optimized treatments are crucial for improving quality of life and functioning.

More Related Videos

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil
09:30

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

Published on: October 4, 2016

Related Experiment Videos

Last Updated: May 17, 2026

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:54

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil
09:30

Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil

Published on: October 4, 2016

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Depression treatment has advanced, yet achieving full remission is difficult.
  • Incomplete remission negatively impacts social, occupational functioning, and quality of life.
  • Barriers include diagnostic accuracy, partial response, medication issues, and residual symptoms.

Purpose of the Study:

  • To highlight the challenges in achieving depression remission.
  • To emphasize the need for improved strategies for depression management.
  • To identify key areas for intervention to enhance treatment outcomes.

Main Methods:

  • Literature review on depression pathophysiology and treatment.
  • Analysis of factors hindering remission.
  • Synthesis of current and novel intervention strategies.

Main Results:

  • Biological understanding of depression has grown, but clinical remission rates remain suboptimal.
  • Accurate diagnosis and addressing residual symptoms are critical.
  • Multifaceted strategies are necessary for effective depression management.

Conclusions:

  • Achieving depression remission requires a comprehensive approach.
  • Destigmatization, patient education, and optimized treatments are essential.
  • Exploring novel interventions and managing residual symptoms are key to improving patient outcomes.