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Related Experiment Videos

[Different sensitivity of sinus node and atrioventricular node to adenosine triphosphate].

T Shirayama1, D Inoue, I Omori

  • 1Second Department of Medicine, Kyoto Prefectural University of Medicine.

Kokyu to Junkan. Respiration & Circulation
|January 1, 1990
PubMed
Summary

Adenosine triphosphate (ATP) affects heart rate differently in the sinus node (SN) and atrioventricular node (AVN). Higher ATP concentrations are needed to slow SN compared to AVN, impacting heart rhythm regulation.

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Area of Science:

  • Cardiovascular Physiology
  • Electrophysiology
  • Pharmacology

Context:

  • The sinus node (SN) and atrioventricular node (AVN) are critical for cardiac rhythm.
  • Adenosine triphosphate (ATP) is known to influence cardiac electrophysiology.
  • Understanding differential nodal responses to ATP is crucial for cardiac function.

Purpose:

  • To investigate the concentration-dependent effects of ATP on the spontaneous cycle length of rabbit SN and AVN.
  • To compare the required ATP concentrations for significant negative chronotropic effects on SN versus AVN.
  • To examine the influence of dipyridamole and theophylline on ATP's chronotropic action.

Summary:

  • Higher adenosine triphosphate (ATP) concentrations were required to significantly prolong the spontaneous cycle length of the sinus node (SN) (10(-5)M) compared to the atrioventricular node (AVN) (10(-6)M).

Related Experiment Videos

  • The negative chronotropic effect of ATP was greater in the AVN than in the SN at concentrations above 10(-6)M.
  • ATP induced hyperpolarization of the maximum diastolic potential (MDP) in both nodes, with a trend towards a greater effect in the AVN, but depolarized MDP at 10(-3)M.

    • Impact:

    • This study elucidates the differential sensitivity of cardiac pacemakers to ATP, providing insights into heart rate regulation.
    • Findings suggest distinct mechanisms underlying ATP's chronotropic effects in the SN and AVN.
    • The results contribute to a deeper understanding of the role of extracellular ATP in cardiac electrophysiology and potential therapeutic interventions.