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Depression and low bone mineral density: The correlation among Chinese
Jaafer M Kurmanji1, Syed Azhar Syed Sulaiman, Lau Kim Kah
1Department of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia.
Asian Journal of Psychiatry
|October 12, 2012
Summary
Depression is linked to lower bone mineral density in Malaysian Chinese individuals. This study found a higher risk of low bone density in those with depression, suggesting a potential connection.
Area of Science:
- Endocrinology and Bone Metabolism
- Psychiatry and Mental Health
Background:
- Depression is associated with hormonal changes, including elevated cortisol and reduced sex hormones.
- These hormonal shifts can negatively impact bone metabolism, leading to decreased bone mineral density and increased fracture risk.
Purpose of the Study:
- To investigate the relationship between low bone density and depression in the Malaysian Chinese population.
Main Methods:
- A study involving 91 Malaysian Chinese adults with depression and 98 controls aged 25-65.
- Bone mineral density was assessed using calcaneus ultrasound bone densitometry (T-score and Z-score).
Main Results:
- The depressed group exhibited significantly lower T-scores for bone mineral density compared to controls (P=0.020).
- Individuals with depression had a 1.5-fold increased risk of low bone density (T-score < -1.0).
- Logistic regression analysis revealed a significant association between depression and low bone mineral density (Odds Ratio = 2.28).
Conclusions:
- Depression may be associated with reduced bone mineral density in the Malaysian Chinese population.
- Findings highlight the importance of considering bone health in individuals with depression.
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