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Related Experiment Video

Updated: May 17, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

Evaluation of right ventricular function in patients with COPD.

Yosuke Tanaka1, Mitsunori Hino, Kyoichi Mizuno

  • 1Department of Respiratory Medicine, Chiba-Hokusoh Hospital, Nippon Medical School, Chiba, Japan.

Respiratory Care
|October 12, 2012
PubMed
Summary

Assessing right ventricular (RV) function using echocardiography can improve prognostication in COPD patients. Noninvasive RV markers correlate with dyspnea and survival, aiding early COPD management.

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10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

Area of Science:

  • Cardiology
  • Pulmonology
  • Medical Imaging

Background:

  • Pulmonary hypertension (PH) is a significant predictor of mortality in Chronic Obstructive Pulmonary Disease (COPD).
  • Current COPD prognostic models lack adequate indicators of right ventricular (RV) function.
  • Accurate assessment of RV function is crucial for managing COPD patients, especially those with PH.

Purpose of the Study:

  • To evaluate the utility of noninvasive RV function markers in routine COPD assessment.
  • To determine if RV function markers improve prognostic models for early-stage COPD.
  • To investigate the correlation between RV function and clinical parameters in COPD patients.

Main Methods:

  • Retrospective review of 49 male COPD patients undergoing cardiac ultrasonography.
  • Comparison of echocardiographic parameters of pulmonary circulation and RV function with physical status and prognosis indices.
  • Analysis of Medical Research Council (MRC) dyspnea scores and survival rates.

Main Results:

  • Subjects with echocardiographic signs of PH had higher MRC dyspnea scores (3.17 ± 1.23 vs 2.26 ± 0.81, P = .02).
  • Significant differences in RV ejection time, isovolumetric relaxation time, and total ejection isovolume index were observed between subjects with and without PH.
  • RV total ejection isovolume index strongly correlated with MRC score (P < .001) and survival rates (HR 5.31 for overall, HR 3.26 for hospital-free).

Conclusions:

  • Incorporating RV function assessment into routine COPD evaluation may be beneficial.
  • Noninvasive echocardiographic markers of RV function provide valuable prognostic information in COPD.
  • These findings support the integration of RV assessment for improved COPD patient management.