Related Experiment Video
Updated: May 17, 2026

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)
Published on: February 5, 2022
Fusion of gemini based cationic liposomes with cell membrane models: implications for their biological activity
Simone Aleandri1, Cecilia Bombelli, Maria Grazia Bonicelli
1Dipartimento di Chimica Università degli Studi di Roma "Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
Abstract:
The interaction of neutral and anionic phospholipid liposomes, used as cell models, with cationic liposomes formulated with 1,2-dimyristoyl-sn-glicero-3-phosphocholine and stereomeric cationic gemini surfactants was investigated by differential scanning calorimetry, fluorescence experiments and dynamic laser light scattering. This study was aimed at rationalizing the different biological features shown by liposomes based on different gemini stereoisomers observed in previous investigations. In fact, to correlate the observed biological activity of liposomes with the molecular structure of their components is critical for a rational and systematic approach to the design of new carriers for drug delivery. The obtained results show that the different stereochemistry of the gemini surfactant controls the interaction and the extent of fusion with different cell models.
More Related Videos
12:18Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
11:10Detergent-free Ultrafast Reconstitution of Membrane Proteins into Lipid Bilayers Using Fusogenic Complementary-charged Proteoliposomes.
Published on: April 5, 2018
Related Concept Videos
The Fluid Mosaic Model
Fluid Mosaic Model
Assembly of the Lipid Bilayer in the ER
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...