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[Design of a high-dynamic closed-loop controlled cartilage test system].

P Föhr¹, V Hautmann, P Prodinger

¹Abteilung für Biomechanik, Klinik für Orthopädie und Sportorthopädie , Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland. foehr@tum.de

|October 12, 2012

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This study presents a high-performance material testing system for evaluating articular cartilage repair. The system enables precise measurement of dynamic recovery profiles for enhanced quality control of cell-based medicinal products.

Area of Science:

Biomedical Engineering
Tissue Engineering
Biomaterials Science

Context:

Current articular cartilage repair methods, including scaffold-based autologous chondrocyte implantation, are clinically applied.
Upcoming European Medicines Agency (EMA) guidelines will mandate enhanced structural analyses for human cell-based medicinal products.
Articular cartilage exhibits complex biphasic and viscoelastic mechanical properties, necessitating advanced testing systems.

Purpose:

To introduce a high-performance material test system for characterizing articular cartilage and replacement materials.
To enable accurate measurement of dynamic recovery profiles essential for quality control.
To meet the stringent requirements for axis acceleration (>50 m/s²) and specimen fixation in biological testing.

Summary:

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Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

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Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

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A novel material test system has been developed, featuring custom components for secure biological specimen fixation.
The system incorporates a sophisticated software package with a graphical user interface and axis controller for highly reproducible tests.
Utilizes high-speed position, velocity, and force controllers (kilohertz speed) for precise application of static and dynamic loading profiles, independent of set points.

Impact:

Facilitates improved quality control for cell-based medicinal products in cartilage repair.
Supports the development and validation of advanced cartilage replacement materials.
Enables detailed characterization of mechanical properties crucial for clinical efficacy and regulatory compliance.