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Related Experiment Videos

Screening for glycosuria during pregnancy.

W J Watson1

  • 1Department of Obstetrics and Gynecology, US Army Hospital, Berlin, West Germany.

Southern Medical Journal
|February 1, 1990
PubMed
Summary

Routine urine glucose screening during pregnancy is not effective for detecting gestational diabetes. This study found that urine glucose levels (glycosuria) have low sensitivity and predictive value for identifying the condition.

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Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Clinical Chemistry

Background:

  • Gestational diabetes mellitus (GDM) screening is recommended between 24-28 weeks of gestation.
  • Urine glucose testing (glycosuria) is often performed at routine prenatal visits.

Purpose of the Study:

  • To evaluate the clinical utility of routine urine glucose screening for gestational diabetes.
  • To compare urine glucose levels with serum glucose tests for GDM detection.

Main Methods:

  • A prospective study of 500 pregnant women.
  • Comparison of random urine glucose values from prenatal visits with a 50 gm oral glucose tolerance test at 28 weeks' gestation.

Main Results:

  • 22 patients (4.4%) were diagnosed with gestational diabetes.
  • 85% of women had some glycosuria, and 19% had severe glycosuria.
  • Only 27% of women with GDM had detectable glycosuria, with a 7.1% positive predictive value for urine glucose screening.

Conclusions:

  • Routine urine glucose screening is not a reliable method for detecting gestational diabetes.
  • Severe glycosuria before 24 weeks may warrant earlier blood glucose screening.
  • Current urine screening practices for glycosuria lack clinical utility after blood glucose screening.

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