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Related Concept Videos

Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Corneal and Limbal Alkali Injury Induction Using a Punch-Trephine Technique in a Mouse Model
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Microbial keratitis following vegetative matter injury.

Mukesh Taneja1, Jatin N Ashar, Anurag Mathur

  • 1Cornea and Anterior Segment Services, L.V. Prasad Eye Institute, Hyderabad, India.

International Ophthalmology
|October 12, 2012
PubMed
Summary

Vegetative matter eye injuries often cause varied infections, with bacterial and polymicrobial keratitis being most common. Avoid empirical antifungal treatment for these injuries, as it may not be effective.

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Area of Science:

  • Ophthalmology
  • Microbiology
  • Infectious Diseases

Background:

  • Corneal infections following trauma, especially with vegetative matter, present a significant clinical challenge.
  • Understanding the microbiological profile is crucial for effective treatment and preventing vision loss.

Purpose of the Study:

  • To analyze the microbiological profile of keratitis cases resulting from vegetative matter trauma.
  • To guide appropriate empirical therapy in such cases.

Main Methods:

  • Retrospective review of 49 patients with keratitis after vegetative matter injury.
  • Corneal scraping for smears and cultures to identify causative organisms.
  • Analysis of culture-negative cases and outcomes with empirical antibacterial therapy.

Main Results:

  • Diverse etiologies were observed: 13 fungal, 8 bacterial, 2 protozoal, 13 polymicrobial, and 13 culture-negative.
  • Polymicrobial infections were predominantly bacterial, with some coexisting fungal and bacterial cases.
  • Culture-negative cases showed varied outcomes, with some improving with therapy and others identified as fungal on biopsy post-keratoplasty.

Conclusions:

  • Corneal infections from vegetative matter trauma have a varied microbiological spectrum, with bacterial and polymicrobial infections being prevalent.
  • Empirical antifungal therapy is not recommended for vegetative matter-induced keratitis due to the diverse etiology.
  • Tailoring treatment based on microbiological findings or clinical suspicion is essential for favorable outcomes.