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Relationship between left ventricular diastolic function and arterial stiffness in asymptomatic patients with

Cornelis J Roos1, Dominique Auger, Roxana Djaberi

  • 1Department of cardiology, C5-P, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands. c.j.roos@lumc.nl

The International Journal of Cardiovascular Imaging
|October 12, 2012
PubMed

Insights

Arterial stiffness, a common issue in diabetes mellitus (DM), is linked to left ventricular (LV) diastolic dysfunction. This study found pulse wave velocity (PWV) independently associated with LV diastolic dysfunction grade in asymptomatic patients with DM.

Area of Science:

  • Cardiology
  • Diabetology
  • Vascular Physiology

Background:

  • Left ventricular (LV) diastolic dysfunction and increased arterial stiffness are prevalent in patients with diabetes mellitus (DM).
  • The precise relationship between these two cardiovascular complications in DM remains incompletely understood.
  • Understanding this link is crucial for managing cardiovascular risk in diabetic populations.

Purpose of the Study:

  • To investigate the relationship between LV diastolic function and arterial stiffness in asymptomatic patients with DM.
  • To assess arterial stiffness using applanation tonometry, measuring parameters like aortic pulse wave velocity (PWV).
  • To correlate arterial stiffness metrics with echocardiographic indices of LV diastolic function.

Main Methods:

  • 142 asymptomatic patients with DM underwent echocardiography for LV diastolic function assessment.
  • Arterial stiffness was evaluated by measuring aortic pulse wave velocity (PWV).
  • Wave reflection was assessed using central systolic blood pressure (cSBP), central pulse pressure (cPP), and augmentation index (AIx) via applanation tonometry.

Main Results:

  • Pulse wave velocity (PWV) was independently associated with the grade of LV diastolic dysfunction (β = 0.76, p = 0.03).
  • Measures of wave reflection (cPP, cSBP, AIx) were independently related to the E/A ratio but not the LV diastolic dysfunction grade.
  • These findings indicate distinct associations between different aspects of arterial function and LV diastolic parameters.

Conclusions:

  • Arterial stiffness and wave reflection parameters are associated with echocardiographic indices of LV diastolic function in asymptomatic DM patients.
  • Therapies targeting arterial stiffness progression and reducing late-systolic pressure overload may mitigate LV diastolic dysfunction in this cohort.
  • Further research is warranted to explore the clinical implications and therapeutic strategies for this patient group.

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