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Updated: May 17, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
Progress in understanding the epigenetic basis for immune development, immune function, and the rising incidence of
David J Martino1, Susan L Prescott
1Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC 3055, Australia. david.martino@mcri.edu.au
Abstract:
The profile of allergic disease worldwide continues to change as the number of severe IgE-mediated allergies increases. This phenomenon is thought to reflect the outcome of combined genetic/environmental/developmental/stochastic effects on immune development, but understanding this remains a challenge. Epigenetic disruption at key immune genes during development has been proposed as a potential explanation for how environmental exposures may alter immune cell development and function. This represents an emerging area of research with the potential to yield new understanding of how disease risk is modified. Here, we examine recent developments in this field that are defining new epigenetic paradigms of allergic disease.
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