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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Association between ankylosing spondylitis and chronic periodontitis: a population-based study.
Joseph J Keller1, Jiunn-Horng Kang, Herng-Ching Lin
1School of Health Care Administration, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Arthritis and Rheumatism
|October 12, 2012
Summary
Ankylosing spondylitis (AS) patients show a higher prevalence of prior chronic periodontitis. This study suggests a significant association between AS and this gum disease, highlighting potential common underlying factors.
Area of Science:
- Rheumatology
- Periodontology
- Public Health
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease.
- Chronic periodontitis is a common gum disease.
- Potential shared underlying factors between AS and chronic periodontitis are suggested but understudied.
Purpose of the Study:
- To investigate the association between ankylosing spondylitis and chronic periodontitis.
- Utilize a population-based dataset from Taiwan for robust analysis.
Main Methods:
- Case-control study design.
- Utilized administrative claims data from Taiwan's National Health Insurance program.
- Included 6,821 AS patients and 34,105 matched controls.
- Conditional logistic regression analysis to determine odds ratios (ORs) and 95% confidence intervals (95% CIs).
Main Results:
- Significantly higher prevalence of prior chronic periodontitis in AS patients (41.5%) compared to controls (25.9%).
- AS patients were 1.84 times more likely to have a prior diagnosis of chronic periodontitis (adjusted OR 1.84 [95% CI 1.74-1.98]).
- Even after excluding patients who underwent periodontal surgery, the association remained significant (adjusted OR 2.04 [95% CI 1.93-2.15]).
Conclusions:
- A significant association exists between ankylosing spondylitis and a prior diagnosis of chronic periodontitis.
- Findings suggest a potential link that warrants further investigation into shared etiologic factors.
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