Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Local hyperthermia to canine prostate. A pilot study.

C Servadio1, Z Leib, A Lev

  • 1Department of Urology, Beilinson Medical Center, Petah Tiqva, Israel.

Urology
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunologic Heterogeneity in 2 Cartilage-Hair Hypoplasia Patients With a Distinct Clinical Course.

Journal of investigational allergology & clinical immunology·2022
Same author

Exogenous interleukin-2 can rescue in-vitro T cell activation and proliferation in patients with a novel capping protein regulator and myosin 1 linker 2 mutation.

Clinical and experimental immunology·2020
Same author

Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis.

Clinical and experimental immunology·2018
Same author

T and B cell clonal expansion in Ras-associated lymphoproliferative disease (RALD) as revealed by next-generation sequencing.

Clinical and experimental immunology·2017
Same author

Co-existence of clonal expanded autologous and transplacental-acquired maternal T cells in recombination activating gene-deficient severe combined immunodeficiency.

Clinical and experimental immunology·2014
Same author

Selective clinical and immune response of the oligoclonal autoreactive T cells in Omenn patients after cyclosporin A treatment.

Clinical and experimental immunology·2012
Same journal

"Editorial Comment on "Vaginal Estrogen Prescription is Associated with Reduced Rates of Serious Adverse Outcomes in Women of All Age Groups With Recurrent Urinary Tract Infection: An Epic Cosmos Database Analysis".

Urology·2026
Same journal

The True Oral History of Buccal Mucosal Grafts for Male Urethral Stricture Repair.

Urology·2026
Same journal

Preventing Postpartum Pelvic Floor Dysfunction: Clinical Evidence and Policy Gaps in U.S. Coverage of Pelvic Floor Muscle Therapy.

Urology·2026
Same journal

Editorial Comment on "Through the Eyes of the Applicant: A Qualitative Study of the Urology Residency Match".

Urology·2026
Same journal

Editorial Comment on "A Histopathologic Assessment of Prostate Ductal Anatomy in Relation to Micro-Ultrasound".

Urology·2026
Same journal

Same-Day Discharge Following Multiport Robot-Assisted Simple Prostatectomy: A Prospective Feasibility Study of Outcomes, Costs, and Post-Discharge Healthcare Utilization.

Urology·2026
See all related articles

Deep microwave hyperthermia treatments in dogs showed elevated white blood cell counts and specific enzyme levels, indicating potential tissue damage in the prostate after localized heating.

Area of Science:

  • Oncology
  • Biomedical Engineering
  • Veterinary Medicine

Background:

  • Localized deep microwave hyperthermia is an emerging therapeutic modality.
  • Accurate temperature monitoring is crucial for effective and safe hyperthermia treatment.
  • Understanding the physiological responses to hyperthermia is essential for clinical application.

Purpose of the Study:

  • To evaluate the safety and efficacy of localized deep microwave hyperthermia applied rectally to the canine prostate.
  • To investigate the temperature distribution and physiological effects of microwave hyperthermia in the prostate.
  • To identify potential biomarkers of treatment response and adverse effects.

Main Methods:

  • A 915 MHz water-cooled skirt-type applicator was used for rectal administration in dogs.

Related Experiment Videos

  • Prostate temperature was maintained at 42.5°C or 44.5°C for 90 minutes to 5 hours.
  • Three-dimensional temperature mapping, rectal wall, and urethral temperatures were monitored using a Luxtron Fluoroptic Unit.

    • Main Results:

    • Monocytosis was observed in differential blood counts for at least one week post-treatment.
    • Elevated creatinine phosphokinase (CPK) and serum glutamic oxaloacetic transaminase (SGOT) levels correlated with histopathologic evidence of localized necrotic damage.
    • The rectal wall and prostatic urethra temperatures were maintained lower than the target prostate temperature.

    Conclusions:

    • Rectal microwave hyperthermia can be delivered to the canine prostate with controlled temperature distribution.
    • Monocytosis and elevated CPK/SGOT may serve as indicators of treatment-induced tissue injury.
    • Further research is warranted to optimize hyperthermia protocols and assess long-term outcomes.