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Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein
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Functional Rescue of F508del-CFTR Using Small Molecule Correctors

Steven Molinski1, Paul D W Eckford, Stan Pasyk

  • 1Programme in Molecular Structure and Function, Research Institute, Hospital for Sick Children Toronto, ON, Canada ; Department of Biochemistry, University of Toronto Toronto, ON, Canada.

Frontiers in Pharmacology
|October 12, 2012
PubMed

Keywords:
F508del-CFTR foldingconformational stabilitydrug discoveryintra-molecular defectssmall molecule correctorstrafficking

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