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Related Experiment Video

Updated: May 17, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Therapeutic options for severe asthma.

Jilcy Mathew¹, Wilbert S Aronow, Dipak Chandy

¹Divisions of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York Medical College, Valhalla, USA.

Archives of Medical Science : AMS

|October 12, 2012

Summary

Severe asthma management is challenging due to limited treatments. Addressing risk factors and comorbidities, alongside exploring diverse therapies like biologics, is crucial for patient care.

Keywords:

severe asthma treatment

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Area of Science:

Pulmonology
Allergy and Immunology

Background:

Asthma prevalence has significantly increased globally.
Severe asthma presents management challenges and imposes a substantial burden on patients.

Purpose of the Study:

To review current and emerging therapeutic strategies for severe asthma.
To highlight the importance of risk factor modification and comorbidity management in severe asthma.

Main Methods:

Literature review of current treatment guidelines and emerging therapies for severe asthma.
Analysis of conventional and novel pharmacological and non-pharmacological interventions.

Main Results:

Effective management requires addressing modifiable risk factors (smoking, allergens, obesity, adherence) and comorbidities (GERD, OSA).
Conventional treatments include inhaled corticosteroids, long-acting β(2) agonists, leukotriene antagonists, and oral corticosteroids.
Novel options encompass immunotherapy, biologics (monoclonal antibodies, TNF-α blockers), PDE inhibitors, antimicrobials, and bronchial thermoplasty.

Conclusions:

A multimodal approach is essential for severe asthma management.
Optimizing risk factor control and comorbidity treatment is fundamental.
A broad spectrum of therapeutic options, from conventional to advanced biologics and procedures, should be considered.