Related Experiment Video

Updated: May 17, 2026

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
09:05

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability

Published on: November 21, 2014

Is helicobacter pylori infection a risk factor for coronary heart disease?

Mehran Rogha1, Marjan Nikvarz, Zahra Pourmoghaddas

  • 1Assistant Professor, Department of Internal Medicine, School of Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran.

ARYA Atherosclerosis
|October 12, 2012
PubMed

Insights

Helicobacter pylori (H. pylori) infection is linked to coronary heart disease (CHD) in Iranians. This risk factor is independent of common conditions like diabetes and hypertension.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • The association between Helicobacter pylori (H. pylori) infection and coronary heart disease (CHD) remains controversial.
  • This study investigates the potential link between H. pylori infection and CHD in an Iranian population.

Purpose of the Study:

  • To evaluate the association between H. pylori infection and the presence of coronary heart disease (CHD).
  • To determine if H. pylori infection is an independent risk factor for CHD.

Main Methods:

  • 112 patients undergoing coronary angiography provided blood samples for H. pylori IgG, C-reactive protein (CRP), and interleukin-6 (IL-6) measurements.
  • Patients were categorized into CHD (n=62) and non-CHD (n=43) groups based on angiography results.
  • Multivariate logistic regression adjusted for age, sex, diabetes mellitus (DM), dyslipidemia (DLP), hypertension (HTN), CRP, and IL-6 levels.

Main Results:

  • Multivariate analysis revealed a significant association between H. pylori infection and CHD (OR 3.18, 95% CI 1.08-9.40).
  • This association remained significant after adjusting for traditional CHD risk factors and inflammatory markers.

Conclusions:

  • H. pylori infection is identified as a probable risk factor for coronary heart disease.
  • The link between H. pylori and CHD is independent of common comorbidities such as DM, DLP, HTN, and inflammatory markers (CRP, IL-6).
Abstract

Keywords:
AngiographyCoronary Heart DiseaseHelicobacter Pylori

More Related Videos

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance05:23

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

Published on: March 7, 2025

Related Concept Videos

Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...