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Molecular Epidemiology of Rotavirus Strains Circulating among Children with Gastroenteritis in Iran

Mohammad Kargar1, Maryam Zare, Akram Najafi

  • 1Department of Microbiology, Jahrom Branch, Islamic Azad University, Jahrom, Iran.

Iranian Journal of Pediatrics
|October 12, 2012
PubMed

Insights

Rotavirus infection affects over 28% of young children with acute gastroenteritis in Marvdasht, Iran. Continuous surveillance is crucial for diarrhea prevention and informing rotavirus vaccine introduction strategies.

Area of Science:

  • Virology
  • Pediatrics
  • Public Health

Background:

  • Rotavirus is a leading cause of severe gastroenteritis in children globally.
  • Understanding regional rotavirus epidemiology and genotypes is vital for effective control strategies.

Purpose of the Study:

  • To determine the prevalence of rotavirus infection in children under five with acute gastroenteritis in Marvdasht, Iran.
  • To identify the circulating rotavirus genotypes in this population.

Main Methods:

  • Stool samples from 141 children (1 month-5 years) with severe diarrhea were analyzed.
  • Enzyme immunoassays (EIA) detected group A rotaviruses.
  • Nested RT-PCR was used for rotavirus genotyping.

Main Results:

  • Rotavirus was detected in 28.37% of children.
  • Infection peaked in summer and was most common in the first two years of life.
  • Mixed G genotypes predominated (60%), with G2, G4, and G1 also detected. G3/G8 mixed infection was reported for the first time in Iran.

Conclusions:

  • High rotavirus prevalence necessitates ongoing surveillance.
  • Monitoring new rotavirus strains is essential for public health policy and vaccine decisions.
Abstract

Keywords:
ChildrenEpidemiologyGastroenteritisGenotypingRotavirus

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