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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Related Experiment Video

Updated: May 17, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Lipedema is associated with increased aortic stiffness.

G Szolnoky1, A Nemes, H Gavallér

  • 1Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary. szolnoky@dermall.hu

Lymphology
|October 13, 2012
PubMed
Summary

Lipedema, a condition causing disproportionate fat, is linked to increased aortic stiffness. This study found lipedema patients have stiffer aortas, suggesting arterial involvement in the disease.

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Last Updated: May 17, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Area of Science:

  • Cardiovascular Physiology
  • Vascular Biology
  • Medical Science

Background:

  • Lipedema is characterized by disproportionate fat distribution, often associated with frequent bruising, capillary fragility, and impaired microcirculation.
  • While venous and lymphatic dysfunction are documented, arterial circulation in lipedema remains understudied.
  • Existing research highlights microangiopathy but lacks comprehensive arterial assessment.

Purpose of the Study:

  • To investigate aortic elastic properties in women with lipedema.
  • To determine if arterial stiffness is a characteristic feature of lipedema.
  • To explore the impact of lipedema on major artery function.

Main Methods:

  • Transthoracic echocardiography was used to assess aortic dimensions and function.
  • Blood pressure measurements and physical examinations were conducted on all participants.
  • Aortic stiffness index (beta), distensibility, and strain were calculated using aortic diameter and blood pressure data.

Main Results:

  • Women with lipedema exhibited significantly larger mean systolic and diastolic aortic diameters compared to controls.
  • Aortic stiffness index (beta) was significantly higher in the lipedema group.
  • Aortic strain and distensibility were significantly lower in patients with lipedema, indicating increased aortic stiffness.

Conclusions:

  • Lipedema is associated with increased aortic stiffness.
  • The findings suggest impaired arterial elasticity is a feature of lipedema.
  • Further research is warranted to understand the implications of aortic stiffness in lipedema pathophysiology.