[Study on the weight-reducing effect of Acer truncatum leave extract in alimentary obesity rat]
Lifang Gao1, Lige Cao, Mi Tian
1Center for Food and Drug Safety Evaluation of Capital Medical University, Beijing 100069, China. lifanggao@ccmu.edu.cn
Objective:
To investigate the weight-reducing effect of Acer truncatum leave extract on alimentary obesity rats and its effect on fatty acid synthase (FAS).
Methods:
SPF-grade adult male Wistar rats were fed with high-fat diet and Acer truncatum leave extract (10, 30 and 100 mg/kg BW) was given by gavage once a day for 31 days. Body weight (BW), adipose weight and food consumption were recorded, and the activity of hepatic fatty acid synthase (FAS) was measured.
Results:
Compared with the model-control group, body weight, adipose weight and the ratio of adipose weight to body weight were obviously lower in 30 mg/kg BW and 100 mg/kg BW groups (P < 0.01). The activity of hepatic FAS in rats administrated with the extract was markedly lower than the control rats (P < 0.05).
Conclusion:
There might have a function of Acer truncatum leave extract on reducing body weight.
