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Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

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Related Experiment Video

Updated: May 17, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Published on: September 11, 2015

[Cell sheet technology and its application in bone tissue engineering].

Yali Chen1, Nuo Zhou, Xuanping Huang

  • 1Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Guangxi Medical University, Nanning Guangxi 530021, PR China.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
|October 13, 2012
PubMed
Summary
This summary is machine-generated.

Cell sheet technology (CST) offers a promising approach for bone tissue engineering by preserving cell-matrix integrity. This method facilitates in vivo bone regeneration and advances the field of engineered bone construction.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Traditional tissue engineering methods often face challenges with cell viability and function post-harvest.
  • Proteolytic enzymes used in conventional techniques can compromise the extracellular matrix and cellular components.

Purpose of the Study:

  • To review the advancements in cell sheet technology (CST).
  • To evaluate the application of CST in the field of bone tissue engineering.

Main Methods:

  • Extensive literature review and analysis of studies on CST.
  • Focus on temperature-responsive culture dishes for cell harvesting.

Main Results:

  • CST enables harvesting of intact cell sheets with their deposited extracellular matrix, avoiding enzyme use.
  • Cell sheets retain biological activity and provide a conducive microenvironment for bone regeneration in vivo.
  • Three-dimensional structures for bone tissue engineering can be created by layering, wrapping scaffolds, or folding cell sheets.

Conclusions:

  • Cell sheet technology presents a viable strategy for bone tissue engineering.
  • Integrating CST with traditional methods will accelerate progress in engineered bone development.