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Updated: May 17, 2026

Transient Treatment of Human Pluripotent Stem Cells with DMSO to Promote Differentiation
Published on: July 17, 2019
[Research progress of cell dedifferentiation induced by reversine]
Xuqi Hu1, Xiaolei Zhang, Yifei Zhou
1Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou Zhejiang 325000, PR China.
Objective:
To review the research progress of different ways of stem cells generation and cells dedifferentiation induced by reversine.
Methods:
The papers related to reversine inducing cells dedifferentiation and stem cells generation were reviewed.
Results:
To obtain stem cells, there are always some disadvantages via somatic cell nuclear transfer or gene transfection. However reversine, a small molecule, can induce cells dedifferentiation which has unique advantage. But its mechanism is still unclear.
Conclusion:
The chemical approach for generation of induced pluripotent stem cells by reversine may take the place of other methods.
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