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Voxel-based morphometric analysis in hypothyroidism using diffeomorphic anatomic registration via an exponentiated
1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), Timarpur, Delhi, India.
Journal of Neuroendocrinology
|October 13, 2012
Summary
Hypothyroidism is linked to brain structural changes in adults. This voxel-based morphometry study found reduced grey and white matter volumes in hypothyroid patients compared to controls.
Area of Science:
- Neuroimaging
- Endocrinology
- Neurology
Background:
- Hypothyroidism can affect cognitive functions.
- Brain morphological changes in adult hypothyroidism are not well understood.
Purpose of the Study:
- To investigate brain morphological differences in adult hypothyroid subjects compared to healthy controls.
- To identify specific brain regions affected by hypothyroidism.
Main Methods:
- Voxel-based morphometry (VBM) with DARTEL.
- High-resolution structural MRI scans.
- Statistical parametric mapping analysis.
Main Results:
- Reduced grey matter volume in the left postcentral gyrus and cerebellum.
- Reduced white matter volume in the cerebellum, right frontal, precentral, occipital, and temporal gyri.
- No significant increase in grey or white matter volume in hypothyroid subjects.
Conclusions:
- Adult hypothyroidism is associated with significant grey and white matter volume reductions in specific brain regions.
- These morphological changes correlate with known functional deficits in attention, language, motor speed, visuospatial processing, and memory.
- This is the first VBM study to demonstrate brain morphological differences in adult hypothyroidism.
