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Related Concept Videos

Protein Folding01:22

Protein Folding

Overview
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
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Protein Organization01:13

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Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

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Related Experiment Video

Updated: May 17, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

RNA locally optimal secondary structures.

Azadeh Saffarian1, Mathieu Giraud, Antoine de Monte

  • 1LIFL-Laboratoire d'Informatique Fondamentale de Lille, UMR 8022, CNRS, Université Lille 1 and Inria, France.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|October 13, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces an efficient algorithm to compute all locally optimal secondary structures for RNA folding. The regliss software, based on this algorithm, is available via a web server for analyzing RNA folding space.

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Area of Science:

  • Computational biology
  • Bioinformatics
  • Molecular biology

Background:

  • RNA secondary structures are crucial for understanding RNA function.
  • Representing the full RNA folding space is computationally challenging.
  • Locally optimal secondary structures offer a comprehensive view of RNA folding possibilities.

Purpose of the Study:

  • To develop an efficient algorithm for computing all locally optimal secondary structures.
  • To implement this algorithm in user-friendly software.
  • To provide a web server for accessible analysis of RNA folding.

Main Methods:

  • Algorithm design for computing locally optimal secondary structures.
  • Incorporation of helical region stability into the folding model.
  • Software implementation (regliss) and web server deployment.

Main Results:

  • An efficient algorithm for calculating all locally optimal secondary structures was developed.
  • The regliss software effectively implements the algorithm.
  • A publicly accessible web server for regliss is now available.

Conclusions:

  • The developed algorithm and regliss software provide an efficient method for exploring RNA folding space.
  • Accessible computational tools are vital for advancing RNA structure-based research.
  • This work facilitates a deeper understanding of RNA secondary structures and their implications.