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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

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Related Experiment Video

Updated: May 17, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

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Right atrial volume and phasic function in pulmonary hypertension.

Takahiro Sato1, Ichizo Tsujino, Noriko Oyama-Manabe

  • 1First Department of Medicine, Hokkaido University Hospital, Japan.

International Journal of Cardiology
|October 13, 2012
PubMed
Summary

Pulmonary hypertension (PH) is linked to a larger right atrium (RA) with reduced reservoir function but increased conduit function. Right atrial ejection fraction (RA EF) varies with PH severity, impacting patient management.

Keywords:
Chronic thromboembolic pulmonary hypertensionMagnetic resonance imagingPulmonary arterial hypertension

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Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Pulmonary Hypertension Research

Background:

  • Limited research exists on right atrial (RA) structure and function in pulmonary hypertension (PH).
  • Understanding RA dynamics is crucial for a comprehensive view of PH pathophysiology.

Purpose of the Study:

  • To evaluate RA volume and phasic function using cardiac magnetic resonance (CMR).
  • To examine the clinical relevance of these RA parameters in PH patients.

Main Methods:

  • Prospective study of 50 PH patients and 21 controls.
  • RA volume and phasic function indices (reservoir, ejection fraction [EF], conduit) assessed via CMR.

Main Results:

  • PH patients exhibited significantly higher maximum RA volume index compared to controls.
  • RA reservoir volume index was lower, while conduit volume index was higher in PH patients.
  • RA EF increased in WHO functional class III PH but decreased in class IV, correlating with hemodynamic and clinical markers.

Conclusions:

  • PH is associated with increased RA size, diminished reservoir function, and enhanced conduit function.
  • RA systolic function (RA EF) shows a biphasic response to PH severity.
  • RA indices offer unique insights into PH management beyond conventional measures.