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Type II collagen distribution in the monkey ear.

T Ishibe1, T J Yoo

  • 1Department of Medicine, Microbiology and Immunology, University of Tennessee, Memphis 88163.

The American Journal of Otology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Type II collagen is found throughout the primate ear, supporting its potential role in Meniere

Area of Science:

  • Otolaryngology
  • Immunology
  • Histology

Background:

  • Autoimmunity targeting type II collagen is implicated in Meniere's disease and otosclerosis.
  • Previous studies found anti-type II collagen antibodies in patients and induced similar lesions in animals.

Purpose of the Study:

  • To investigate the distribution of type II collagen within the nonhuman primate ear.
  • To assess the potential of type II collagen as an autoantigen in inner ear disorders.

Main Methods:

  • Immunohistochemical analysis using monoclonal antibodies.
  • Examination of nonhuman primate temporal bone sections.

Main Results:

  • Type II collagen was identified in numerous ear structures, including cartilage, membranes, and bone.

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  • Specific locations include the auricle, tympanic membrane, ossicles, otic capsule, and cochlear/vestibular sensory areas.

    • Conclusions:

    • Type II collagen is a significant component of the primate ear.
    • Its widespread distribution supports its consideration as a key factor in the pathogenesis of certain ear diseases.