Is my blood mine? Some comments on the Convention on Human Rights and Biomedicine

We present a protocol for efficient, bulk, and rapid chemical reversion of conventional lineage-primed human pluripotent stem cells (hPSC) into an epigenomically-stable naïve preimplantation epiblast-like pluripotent state. This method results in decreased lineage-primed gene expression and marked improvement in directed multilineage differentiation across a broad repertoire of conventional hPSC...

Establishment of human models of the blood-brain barrier (BBB) can benefit research into brain conditions associated with BBB failure. We describe here an improved technique for preparation of a contact BBB model, which permits coculturing of human astrocytes and brain endothelial cells on the opposite sides of a porous...

Property rights refer to the legal control or ownership that individuals or entities have over a good or resource. These rights determine who can use the resource and under what conditions. Property rights describe the ability to use, sell, lease, or transfer ownership of a good or resource. Clearly defined property rights also delineate the responsibilities of such ownership, such as preventing harm to third parties.  Property rights are essential in ensuring efficient market allocations...

When analyzing a beam subjected to various loads, it is crucial to understand the internal forces and moments generated within the structure. These internal forces can be broadly classified into normal forces, shear forces, and bending moments. To determine these forces and moments, we use the method of sections and apply a specific sign convention based on their direction and the side of the section being analyzed.
The normal force acts perpendicular to the beam's cross-section and can...

When a carbonyl compound is treated with a strong base, the α position gets deprotonated to give a resonance-stabilized intermediate called an enolate. Enolates are ambident nucleophiles because they possess two nucleophilic sites that can attack an electrophile owing to the delocalization of the negative charge between the α carbon and oxygen atoms. When the oxygen atom attacks an electrophile, it is called O-attack, whereas electrophilic attack via the α carbon is known as...

According to the landmark 1999 Institute of Medicine report To Err is Human: Building a Safer Health System, medication errors are a leading cause of preventable harm and death in hospitals. To mitigate these errors and enhance patient safety, nurses must consistently adhere to the Ten Rights of medication administration. These include the right patient, right medication, right dose, right time, right route, right documentation, right education, right to refuse, right assessment, and right...