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Respiratory activity in retrotrapezoid nucleus in cat
C A Connelly1, H H Ellenberger, J L Feldman
1Department of Kinesiology, University of California, Los Angeles 90024-1568.
The American Journal of Physiology
|February 1, 1990
Summary
Neurons in the retrotrapezoid nucleus influence breathing patterns. This study shows these neurons project to the ventral respiratory group, affecting respiratory timing and pattern.
Area of Science:
- Neuroscience
- Respiratory Physiology
Background:
- Previous work identified retrotrapezoid nucleus projections to the ventral respiratory group in cats.
- The functional properties of these retrotrapezoid nucleus neurons remain incompletely understood.
Purpose of the Study:
- To investigate the properties of neurons within the retrotrapezoid nucleus.
- To determine the influence of retrotrapezoid nucleus activity on respiratory motor output.
Main Methods:
- Extracellular recordings were performed in anesthetized, paralyzed, mechanically ventilated cats.
- Neurons in the retrotrapezoid nucleus were identified and characterized by their discharge patterns.
- Chemical and electrical stimulation techniques were used to probe neuronal function and connectivity.
Main Results:
- Respiratory-modulated and spontaneous neuronal activity was recorded in the retrotrapezoid nucleus.
- Twelve respiratory-modulated units showed inspiratory, expiratory, or multimodal discharge patterns.
- Stimulation of the retrotrapezoid nucleus affected respiratory motor output, inducing premature inspiration.
Conclusions:
- Neurons in the retrotrapezoid nucleus exhibit respiratory-modulated activity.
- These neurons project to and interact with the ventral respiratory group.
- Retrotrapezoid nucleus projections likely play a role in regulating respiratory timing and pattern.