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A Human Peripheral Blood Mononuclear Cell (PBMC) Engrafted Humanized Xenograft Model for Translational Immuno-oncology (I-O) Research
Published on: August 15, 2019
Humanized mice for immune system investigation: progress, promise and challenges
Leonard D Shultz1, Michael A Brehm, J Victor Garcia-Martinez
1Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. lds@jax.org
Nature Reviews. Immunology
|October 13, 2012
Summary
Humanized mouse models, developed from immunodeficient mice, now allow for studying the human immune system in vivo. These advanced models offer insights into immune biology and function.
Area of Science:
- Immunology
- Genetics
- Animal Models
Background:
- Severely immunodeficient mouse strains with mutations in the interleukin-2 receptor common γ-chain locus are crucial.
- These mice support the engraftment of a functional human immune system.
Purpose of the Study:
- To review recent advances in the development and use of humanized mice.
- To discuss lessons learned, challenges, and future potential for studying human immunology in vivo.
Main Methods:
- Development of genetically modified immunodeficient mice.
- Engraftment of human immune system components into mice.
- In vivo analysis of human immune cell development and function.
Main Results:
- Humanized mice enable detailed analyses of human immune biology.
- Significant advances in understanding in vivo human immune functions.
- Successful engraftment and function of human immune systems observed.
Conclusions:
- Humanized mice are powerful tools for in vivo human immunology research.
- Continued development holds promise for further insights into immune diseases.
- Addressing remaining challenges will enhance their utility.
