Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 17, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

D-Limonene modulates T lymphocyte activity and viability.

Courtney M Lappas1, Nicholas T Lappas

  • 1Department of Biology, Lebanon Valley College, Annville, PA 17003, United States. lappas@lvc.edu

Cellular Immunology
|October 13, 2012
PubMed
Summary

d-Limonene and its metabolites inhibit key immune cell functions and can cause cell death. These findings highlight d-limonene's immunomodulatory effects, crucial for its therapeutic and commercial applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The naturalness bias.

Current opinion in psychology·2025
Same author

Editorial: Modulation of T-cell function and survival by the tumor microenvironment.

Frontiers in cell and developmental biology·2023
Same author

The Naturalness Bias Influences Drug and Vaccine Decisions across Cultures.

Medical decision making : an international journal of the Society for Medical Decision Making·2022
Same author

Religiosity and the Naturalness Bias in Drug and Vaccine Choices.

Journal of religion and health·2022
Same author

Predictors of the intention to receive a SARS-CoV-2 vaccine.

Journal of public health (Oxford, England)·2021
Same author

Utilizing loop-mediated isothermal amplification to detect the presence of Escherichia coli: An inquiry-driven undergraduate laboratory module.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology·2020

Area of Science:

  • Immunology
  • Natural Products Chemistry

Background:

  • d-Limonene, a cyclic terpene from plant essential oils, is widely used in consumer products.
  • d-Limonene exhibits chemopreventative and chemotherapeutic properties.
  • Limited research exists on d-limonene's impact on immune system function.

Purpose of the Study:

  • To investigate the immunomodulatory effects of d-limonene and its metabolites.
  • To assess the impact on T lymphocyte cytokine production and activation markers.
  • To determine the effects on T lymphocyte viability.

Main Methods:

  • Treatment of T lymphocytes (CD3(+)CD4(+) and CD3(+)CD8(+)) with d-limonene, limonene-1-2-diol, and perillic acid.
  • Measurement of cytokine production (IFN-γ, IL-2, TNF-α, IL-4, IL-13).

More Related Videos

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
11:34

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

Published on: April 11, 2025

Related Experiment Videos

Last Updated: May 17, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
11:34

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

Published on: April 11, 2025

  • Analysis of T lymphocyte activation markers (CD25, CD69, CD40L) and cell death.

    • Main Results:

    • d-Limonene and its metabolites inhibited the production of key cytokines (IFN-γ, IL-2, TNF-α, IL-4, IL-13) by T cells.
    • Modulation of T lymphocyte activation markers (CD25, CD69, CD40L) was observed.
    • High concentrations of these compounds induced T lymphocyte cell death.

    Conclusions:

    • d-Limonene exhibits significant immunomodulatory activity.
    • The effects on T cell cytokine production, activation, and viability are dose-dependent.
    • These immunomodulatory properties are important considerations for therapeutic and commercial use of d-limonene.