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Updated: May 17, 2026

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

Published on: January 13, 2023

Does chlorhexidine prevent dry socket?

Derek Richards¹

¹Centre for Evidence-based Dentistry, Oxford, UK.

Evidence-Based Dentistry

|October 13, 2012

Summary

This summary is machine-generated.

This review found limited evidence that chlorhexidine may reduce alveolar osteitis (AO) after third molar removal. However, the evidence is weak, and more high-quality trials are needed to confirm its effectiveness.

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Last Updated: May 17, 2026

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Published on: April 28, 2022

Area of Science:

Oral and Maxillofacial Surgery
Evidence-Based Dentistry
Pharmacology

Background:

Alveolar osteitis (AO), or dry socket, is a common complication following tooth extraction, particularly third molar removal.
Preventive strategies aim to reduce AO incidence and associated patient morbidity.

Purpose of the Study:

To systematically review the evidence on the efficacy of chlorhexidine in preventing alveolar osteitis.
To assess the quality of existing randomized controlled trials (RCTs) on this topic.

Main Methods:

A comprehensive literature search was conducted across multiple databases (PubMed, Cochrane Library, etc.).
Included were prospective, two-arm (or more) clinical studies evaluating AO incidence.
Data extraction and quality assessment were performed independently by two reviewers, with meta-analysis for homogeneous data.

Main Results:

Ten RCTs were included, mostly involving third molar extraction.
Only two of six evaluated chlorhexidine application protocols (0.2% gel or 0.12% rinse) showed a significant decrease in AO incidence compared to placebo.
Publication bias was assessed using funnel plots and Egger's regression.

Conclusions:

The current evidence supporting chlorhexidine for AO prevention is weak due to high risk of bias in included studies.
While chlorhexidine did not show significantly higher adverse reactions than placebo, its effectiveness remains uncertain.
High-quality RCTs are necessary to establish conclusive evidence on chlorhexidine's role in AO prevention.